منابع مشابه
Running title: Urinary angiotensinogen in proteinuric nephropathies
Assessment of urinary angiotensinogen as a marker of podocyte injury in proteinuric 1 nephropathies 2 3 Masahiro Eriguchi , Ryusuke Yotsueda , Kumiko Torisu , Yasuhiro Kawai , 4 Shoko Hasegawa , Shigeru Tanaka , Hideko Noguchi , Kosuke Masutani , 5 Takanari Kitazono , Kazuhiko Tsuruya 1, 2, * 6 7 1 Department of Medicine and Clinical Science, Graduate School of Medical Sciences, 8 Kyushu Univer...
متن کاملInvolvement of the Tubular ClC-Type Exchanger ClC-5 in Glomeruli of Human Proteinuric Nephropathies
UNLABELLED Glomerular protein handling mechanisms have received much attention in studies of nephrotic syndrome. Histopathological findings in renal biopsies from severely proteinuric patients support the likelihood of protein endocytosis by podocytes. ClC-5 is involved in the endocytosis of albumin in the proximal tubule. AIM To investigate whether ClC-5 is expressed in the glomerular compar...
متن کاملCD36 mediates proximal tubular binding and uptake of albumin and is upregulated in proteinuric nephropathies.
Dysregulation of renal tubular protein handling in proteinuria contributes to the development of chronic kidney disease. We investigated the role of CD36 as a novel candidate mediator of albumin binding and endocytosis in the kidney proximal tubule using both in vitro and in vivo approaches, and in nephrotic patient renal biopsy samples. In CD36-transfected opossum kidney proximal tubular cells...
متن کاملProximal Tubular Expression Patterns of Megalin and Cubilin in Proteinuric Nephropathies
Introduction Receptor-mediated endocytosis is responsible for protein reabsorption in the proximal tubules. For albumin this process involves at least 2 interacting receptors, megalin and cubilin. Albumin is not usually present in the urine, indicating a highly efficient tubular reuptake under physiological conditions. However, early appearance of albuminuria may mean that the tubular system is...
متن کاملPerinatal nephropathies.
The purpose of this paper is to review the development of the mammalian kidney and to assess the influence that various perinatal manipulations may have on the developmental process either morphologically or functionally. Immature kidneys in general have less functional capacity than adult kidneys and a low rate of glomerular filtration, perhaps related to renal blood flow, which appears to lim...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2016
ISSN: 1460-2385,0931-0509
DOI: 10.1093/ndt/gfw183.09